OrthoBiologic Therapy

A New, Minimally-Invasive Approach for Pain and Injury

OrthoBiologics is an innovative new approach designed to treat some orthopaedic injury and disease conditions. Various OrthoBiologic treatments can promote healing, decrease inflammation, and repair damaged tissues often without the invasiveness of surgical intervention. In select cases, however, OrthoBiologic treatments involve operative intervention.

Some naturally occurring cells in the body have the ability to differentiate and promote the repair and regeneration of a variety of damaged tissues. With OrthoBiologic therapy, we use these cells to create a concentrated treatment that frequently is administered with a simple injection and occasionally in conjunction with surgery.

orthobiological therapy process
Johnathan Perry - Tri-City Orthopaedics

With FDA clearance, strong scientific evidence, and teams of scientists and physicians, Dr. Perry at Tri City Orthopaedics has decided to add this option to help people currently struggling with a variety of orthopaedic issues.

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What Conditions Can OrthoBiologics Treat?

OrthoBiologics can help treat a variety of acute and chronic cartilage, tendon, ligament, and muscle injuries including:

  • Mild to severe osteoarthritis/degenerative arthritis of the joints, especially in the shoulder and knee but other joints as well

  • Tendon injuries diseases including some rotator cuff tears and tennis elbow

  • Articular cartilage injuries

How Does OrthoBiologic Therapy work?

There are four types of OrthoBiologic therapy that Dr. Perry offers at TCO.



Platelet-Rich Plasma (PRP)

Platelet-rich plasma is a component of blood that plays a central role in tissue healing and repair. PRP contains platelets, growth factors, and variable amount of white blood cells which work together to activate the body’s natural healing process while reducing inflammation.


Articular Cartilage (The MACI Procedure)

Articular cartilage is the smooth, almost friction-free, connective tissue that covers the ends of bones as they meet at the joint. Arthritis is essentially a breakdown or loss of this coating.  Chondrocytes, the cellular component of healthy articular cartilage tissue, play an important role in restoring damaged or degenerated cartilage in the knee when placed at the site of cartilage injury.


Fat is a remarkably high-quality tissue which contains 100-500 times more reparative cells compared to other tissues in the body such as bone marrow. In fact, fat is the highest quality tissue retaining its reparative processes even as a person ages. The molecular structure of fat also provides cushion and support which is often beneficial when treating orthopaedic conditions.

Articular Cartilage Graft (Osteochondral Transfer)

Because articular cartilage is such a crucial structure in all joints, cartilage injuries can be extremely painful. A graft of healthy cartilage and bone that is transferred to replace the injured cartilage can successfully treat the pain and swelling associated with these injuries while providing the necessary joint cushion and smooth movement.

Ready to Talk to Dr. Perry About OrthoBiologic Therapy?

Johnathan R. Perry, MD - Tri-City Orthopaedics

Johnathan R. Perry, MD

Johnathan R. Perry, MD, one of TCO’s fellowship-trained sports medicine physicians, is committed to exceptional care and individualized treatment, both surgical and non-surgical, for athletes and all patients at every level. He is also well-versed in safe Orthobiologic treatment options and their expert implementation. He strives to help patients return to their active lifestyles and to prevent future injuries from occurring.